gastroplus simulations  (DILIsym Services Inc)

Journal: Pharmaceuticals

Article Title: Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

doi: 10.3390/ph14060545

Figure Lengend Snippet: The minimal physiologically based pharmacokinetic model with two tissue compartments. A single K p value ( K p 1 = K p 2 ) was used in the joint fitting, while the cardiac output ( Q C O ) was divided into tissue blood flow to each compartment ( Q 1 + Q 2 = Q C O ) in the separate fittings. Symbols are defined in the text and in and Table 5 (see below).

Article Snippet: The K p values from two calculation methods (i.e., Poulin and Theil [ ], and Berezhkovskiy [ ]) were applied for the prediction of V S S amongst the four methods found in the GastroPlus PBPK simulator (version 9.8.0002; Simulations Plus, Inc., Lancaster, CA, USA).

Techniques:

Journal: Pharmaceuticals

Article Title: Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

doi: 10.3390/ph14060545

Figure Lengend Snippet: Simultaneous fitting of metformin pharmacokinetics dosed intravenously in 9 species to the minimal physiologically based pharmacokinetic model in . Fitted profiles are in separate panels for visual clarification for the indicated species. The doses and fitted parameters are listed in and . The three curves for man are for different doses from three studies.

Article Snippet: The K p values from two calculation methods (i.e., Poulin and Theil [ ], and Berezhkovskiy [ ]) were applied for the prediction of V S S amongst the four methods found in the GastroPlus PBPK simulator (version 9.8.0002; Simulations Plus, Inc., Lancaster, CA, USA).

Techniques: Drug discovery, Clarification Assay

Journal: Pharmaceuticals

Article Title: Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

doi: 10.3390/ph14060545

Figure Lengend Snippet: Pharmacokinetic parameters of metformin jointly fitted to the minimal physiologically based pharmacokinetic model across 9 species a,b .

Article Snippet: The K p values from two calculation methods (i.e., Poulin and Theil [ ], and Berezhkovskiy [ ]) were applied for the prediction of V S S amongst the four methods found in the GastroPlus PBPK simulator (version 9.8.0002; Simulations Plus, Inc., Lancaster, CA, USA).

Techniques:

Journal: Pharmaceuticals

Article Title: Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

doi: 10.3390/ph14060545

Figure Lengend Snippet: A priori in silico calculation of the tissue distribution parameters ( K p and f d ) for 11 typical tissues of rats in the WB-PBPK. The K p values were predicted using the Poulin and Theil [ 81 ] and Berezhkovskiy [ 82 ] methods built in the GastroPlus PBPK simulator, except for the gut. In vitro PAMPA P (0.5 × 10 −6 cm/s) and fitted P (0.0102 × 10 −6 cm/s) were used to calculate the mean transit time ( M T T ).

Article Snippet: The K p values from two calculation methods (i.e., Poulin and Theil [ ], and Berezhkovskiy [ ]) were applied for the prediction of V S S amongst the four methods found in the GastroPlus PBPK simulator (version 9.8.0002; Simulations Plus, Inc., Lancaster, CA, USA).

Techniques: In Silico, In Vitro, PAMPA Assay, In Vivo

Journal: Pharmaceuticals

Article Title: Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species

doi: 10.3390/ph14060545

Figure Lengend Snippet: Pharmacokinetic parameters of metformin separately fitted to the minimal physiologically based pharmacokinetic model across 9 species.

Article Snippet: The K p values from two calculation methods (i.e., Poulin and Theil [ ], and Berezhkovskiy [ ]) were applied for the prediction of V S S amongst the four methods found in the GastroPlus PBPK simulator (version 9.8.0002; Simulations Plus, Inc., Lancaster, CA, USA).

Techniques: